تعیین عوامل مؤثر بر بقا در اطفال مبتلا به نوروبلاستوما

ABSTRACT Neuroblastoma is a tumor with neural cells origin. It usually originated from adrenal gland and sympathetic ganglions. This tumor is the most common tumor in infants and is in forth grade amonge tumors in childhood. In this reaserch we determine to study the prognostic factors in survival of children with neuroblastoma.This is an analytic cross- sectional reaserch on 119 children with neuroblastoma admitted in oncology service of Ali Asghar hospital from 1986 to 2001. In each case Demographic indicators, signs, symptoms, initial paraclinics, examination, stage of tumors, Kind of chemotherapy and whether the patient is alive or dead was observed. In statistic study Acturial, Kaplan meir survival Analysis and cox regression was used. Median of survival time in this study was 33.33 month. Mean of survival time in female was significantly longer than male [Exp(B) = 0.59, P= 0.04]. Mean of survival time in patients younger than 1 years old, were significantly better than others [Exp(B)= 0.31, P= 0.008]. We understood that having no metastasis engagement increased the survival time of the patients. [Exp(B)= 0.44, P= 0.03]. If the patient is female, younger than 1 year old, dosen’t have any metastasis, and if there is no engagement of bone marrows, there are better prognosis. Of course as you know Ali Asghar oncology center is one of the refferal center in pediatrics oncology, then almost all patients who are reffered to this center are in a high stage of tumor So the survival time which is determined in this study is probably lower than the real survival time of patients with neuroblastoma in all over Iran.